Evaluation of 2% Bromelain gel and 0.2% Chlorhexidine Gel as Subgingival Local Drug Delivery following Scaling and Root Planing in Stage II / III and Grade B Periodontitis - Randomized Controlled Clinical Trial
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Abstract
Background and objectives: Nonsurgical periodontal therapy is the backbone of oral health. The present randomized clinical trial includes the preparation and placement of a herbal medicament adjunctive for periodontitis. Our study includes a comparative evaluation of 2% Bromelain gel with 0.2% Chlorhexidine (CHX) gel as Subgingival Local Drug Delivery (LDD) following Scaling and Root Planing (SRP) in Stage II / III and Grade B Periodontitis.
Methods: Preparation of 2% Bromelain gel and 0.2% Chlorhexidine gel was executed at the Department of Biotechnology, Sir M. Visvesvaraya Institute of Technology, Bengaluru, Karnataka 562157, India. Prepared gels were evaluated in vitro, and the Concentration of Bromelain was set at 2% and Chlorhexidine (CHX) at 0.2%. Clinically, Patients with Stage II / III and Grade B periodontitis underwent scaling and root planning (SRP) and were divided into 3 groups. Randomisation and allocation were done as probing sites receiving only SRP, SRP with adjunct 2% Bromelain gel, and SRP with 0.2% Chlorhexidine gel as groups, respectively. Clinical parameters were assessed at baseline following SRP, at the end of 1 month, and at 3 months. Values obtained were subjected to statistical analysis (p < 0.05).
Results: All the groups show a reduction in all the clinical parameters. Reduction was significantly noted in sites receiving 2% Bromelain gel and 0.2% Chlorhexidine gel adjunct than only SRP. 2% Bromelain gel showed a much greater reduction in inflammation at the end of 1month than 0.2% Chlorhexidine gel. Correlation of clinical variables with time interval showed positive correlation for Gingival Index and modified Sulcular Bleeding Index for the Bromelain group.
Conclusion: Within the scope of this study, Local Drug Delivery using 2% Bromelain and 0.2% Chlorhexidine gel as adjuncts to Scaling and Root Planning demonstrated notable early clinical improvements in the treatment of Stage II/III and Grade B periodontitis.
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