Abstract

Review Article

Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies

Wafaa Saleh*, Jilan M Youssef, Fatma Ata, Mohamed M Anees, Seunghee Cha and Joseph Katz

Published: 14 October, 2021 | Volume 5 - Issue 1 | Pages: 005-011

Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease. The potential risk of malignant transformation in OLP remains controversial. The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. We focused our search to include most of the studies that reported malignant transformation of oral lichen planus using different combinations of the following key indexing terms: oral lichen planus, malignant transformation, smoking, alcohol, chronic inflammation, candida, human papillomavirus (HPV), hepatitis C virus (HCV) and immunosuppression. The animal studies were excluded from our study. Despite a dearth of studies on this topic we have identified consumption of tobacco and/or alcohol, the presence of erosive and/or atrophic areas, infection with candida, HCV, HPV, and immunosuppression as significant cofactors. Patients with OLP with these risk co-factors are at risk of malignant transformation should, therefore be followed up for an extensive period or even for life.

Read Full Article HTML DOI: 10.29328/journal.jcad.1001024 Cite this Article Read Full Article PDF

Keywords:

Oral lichen planus; Malignant transformation; Squamous cell carcinoma

References

  1. Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. ScientificWorldJournal. 2014; 2014: 742826. PubMed: https://pubmed.ncbi.nlm.nih.gov/24672362/
  2. Bardellini E, Amadori F, Flocchini P, Bonadeo S, Majorana A. Clinicopathological features and malignant transformation of oral lichen planus: a 12-years retrospective study. Acta Odontol Scand. 2013. 71: 834-840. PubMed: https://pubmed.ncbi.nlm.nih.gov/23116326/
  3. Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016; 308: 539-551. PubMed: https://pubmed.ncbi.nlm.nih.gov/27349424/
  4. Gonzalez-Moles MA, Ruiz-Ávila I, González-Ruiz L, Ayén A, Gil-Montoya JA, et al. Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis. Oral Oncol. 2019; 96: 121-130. PubMed: https://pubmed.ncbi.nlm.nih.gov/31422203/
  5. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT. Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv). 2018; 60: 528-535. PubMed: https://pubmed.ncbi.nlm.nih.gov/31188760/
  6. Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol. 2010; 28: 100-108. PubMed: https://pubmed.ncbi.nlm.nih.gov/20082959/
  7. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, et al. Pathogenesis of oral lichen planus--a review. J Oral Pathol Med. 2010; 39: 729-734. PubMed: https://pubmed.ncbi.nlm.nih.gov/20923445/
  8. Kaplan I, Ventura-Sharabi Y, Gal G, Calderon S, Anavi Y. The dynamics of oral lichen planus: a retrospective clinicopathological study. Head Neck Pathol. 2012; 6: 178-183. PubMed: https://pubmed.ncbi.nlm.nih.gov/22160614/
  9. Gonzalez-Moles MA, Scully C, Gil-Montoya JA, Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 2008; 14: 229-243. PubMed: https://pubmed.ncbi.nlm.nih.gov/18298420/
  10. Fleskens S, Slootweg P. Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility. Head Neck Oncol. 2009; 1: 11. PubMed: https://pubmed.ncbi.nlm.nih.gov/19432960/
  11. Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002; 46: 207-214. PubMed: https://pubmed.ncbi.nlm.nih.gov/11807431/
  12. Mignogna MD, Muzio LL, Russo LL, Fedele S, Ruoppo E, et al. Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience. Oral Oncol. 2001; 37: 262-267. PubMed: https://pubmed.ncbi.nlm.nih.gov/11287280/
  13. Georgakopoulou EA, Achtari MD, Achtaris M, Foukas PG, Kotsinas A. Oral lichen planus as a preneoplastic inflammatory model. J Biomed Biotechnol. 2012; 2012: 759626. PubMed: https://pubmed.ncbi.nlm.nih.gov/22675259/
  14. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008; 454: 436-444. PubMed: https://pubmed.ncbi.nlm.nih.gov/18650914/
  15. Mohtasham N, Mahdavi-Shahri N, Salehinejad J, Ejtehadi H, Torabi-Parizi M, et al. Detection of nucleoproteins in squamous cell carcinoma, and dysplastic and normal mucosa in the oral cavity by methyl green-pyronin staining. J Oral Sci. 2010; 52: 239-243. PubMed: https://pubmed.ncbi.nlm.nih.gov/20587947/
  16. Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, et al. IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect. 2015; 123: 507-514. PubMed: https://pubmed.ncbi.nlm.nih.gov/25712798/
  17. Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol, 2015; 8: 11884-1194. PubMed: https://pubmed.ncbi.nlm.nih.gov/26617944/
  18. Reidy JT, McHugh EE, Stassen LF. A review of the role of alcohol in the pathogenesis of oral cancer and the link between alcohol-containing mouthrinses and oral cancer. J Ir Dent Assoc. 2011; 57: 200-202. PubMed: https://pubmed.ncbi.nlm.nih.gov/21922995/
  19. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017; 68: 92-102. PubMed: https://pubmed.ncbi.nlm.nih.gov/28438300/
  20. van der Meij EH, Schepman KP, Smeele LE, van der Wal JE, Bezemer PD, et al. A review of the recent literature regarding malignant transformation of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 88: 307-310. PubMed: https://pubmed.ncbi.nlm.nih.gov/10503859/
  21. Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma--an update. CA Cancer J Clin. 2015. 65: 401-421. PubMed: https://pubmed.ncbi.nlm.nih.gov/26215712/
  22. Mignogna MD, Fedele S, Russo LL, Muzio LL, Bucci E. Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence? Oral Oncol. 2004; 40: 120-130. PubMed: https://pubmed.ncbi.nlm.nih.gov/14693234/
  23. Liu Y, Messadi DV, Wu H, Hu S. Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer. Med Hypotheses. 2010; 75: 492-494. PubMed: https://pubmed.ncbi.nlm.nih.gov/20674185/
  24. Sun Y, Liu N, Guan X, Wu H, Sun Z, et al. Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma. Mediators Inflamm. 2016; 2016: 5715719. PubMed: https://pubmed.ncbi.nlm.nih.gov/28053372/
  25. Szarka K, Tar I, Fehér E, Gáll T, Kis A, et al. Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential. Oral Microbiol Immunol. 2009; 24: 314-318. PubMed: https://pubmed.ncbi.nlm.nih.gov/19572894/
  26. Canto AM, Müller H, de Freitas RR, da Silva Santos PS. Oral lichen planus (OLP): clinical and complementary diagnosis. An Bras Dermatol. 2010. 85: 669-675. PubMed: https://pubmed.ncbi.nlm.nih.gov/21152791/
  27. Agha-Hosseini F, Sheykhbahaei N, SadrZadeh-Afshar MS. Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review. J Contemp Dent Pract. 2016; 17: 692-701. PubMed: https://pubmed.ncbi.nlm.nih.gov/27659090/
  28. Bascones C, Gonzalez-Moles MA, Esparza G, Bravo M, Acevedo A, et al. Apoptosis and cell cycle arrest in oral lichen planus Hypothesis on their possible influence on its malignant transformation. Arch Oral Biol. 2005; 50: 873-881. PubMed: https://pubmed.ncbi.nlm.nih.gov/16137496/
  29. Rhodus NL, Cheng B, Myers S, Miller L, Ho V, et al. The feasibility of monitoring NF-kappaB associated cytokines: TNF-alpha, IL-1alpha, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus. Mol Carcinog. 2005; 44: 77-82. PubMed: https://pubmed.ncbi.nlm.nih.gov/16075467/
  30. Lafaurie GI, Perdomo SJ, Buenahora MR, Amaya S, Díaz-Báez D. Human papilloma virus: An etiological and prognostic factor for oral cancer? J Investig Clin Dent. 2018; 9: e12313. PubMed: https://pubmed.ncbi.nlm.nih.gov/29322686/
  31. Pol CA, Ghige SK, Gosavi SR. Role of human papilloma virus-16 in the pathogenesis of oral lichen planus--an immunohistochemical study. Int Dent J. 2015; 65: 11-14. PubMed: https://pubmed.ncbi.nlm.nih.gov/25256345/
  32. Yildirim B, Senguven B, Demir C. Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus. Med Oral Patol Oral Cir Bucal. 2011; 16: e170-174. PubMed: https://pubmed.ncbi.nlm.nih.gov/21196875/
  33. Liu T, Zhang H, Yang X, Li X, Shi Y, et al. Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation. Pathol Res Pract. 2018; 214: 296-302. PubMed: https://pubmed.ncbi.nlm.nih.gov/29254790/
  34. Mattila R, Rautava J, Syrjänen S. Human papillomavirus in oral atrophic lichen planus lesions. Oral Oncol. 2012; 48: 980-984. PubMed: https://pubmed.ncbi.nlm.nih.gov/22658678/
  35. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011; 333: 1154-1157. PubMed: https://pubmed.ncbi.nlm.nih.gov/21798897/
  36. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis. 2019; 25: 693-709. PubMed: https://pubmed.ncbi.nlm.nih.gov/29738106/
  37. Singh SK, Gupta A, Rajan SY, Padmavathi BN, Mamatha GP, et al. Correlation of presence of Candida and epithelial dysplasia in oral mucosal lesions. J Clin Diagn Res. 2014; 8:  Zc31-305. PubMed: https://pubmed.ncbi.nlm.nih.gov/25478443/
  38. Bombeccari GP, Gianni AB, Spadari F. Oral Candida colonization and oral lichen planus. Oral Dis. 2017; 23: 1009-1010. PubMed: https://pubmed.ncbi.nlm.nih.gov/28415152/
  39. McCullough M, Jaber M, Barrett AW, Bain L, Speight PM, et al. Oral yeast carriage correlates with presence of oral epithelial dysplasia. Oral Oncol. 2002; 38: 391-393. PubMed: https://pubmed.ncbi.nlm.nih.gov/12076705/
  40. Kragelund C, Kieffer-Kristensen L, Reibel J, Bennett EP. Oral candidosis in lichen planus: the diagnostic approach is of major therapeutic importance. Clini Oral Investigations. 2013; 17: 957-965. PubMed: https://pubmed.ncbi.nlm.nih.gov/22699660/
  41. Artico G, Freitas RS, Santos Filho AM, Benard G, Romiti R, et al. Prevalence of Candida spp, xerostomia, and hyposalivation in oral lichen planus--a controlled study. Oral Dis. 2014; 20: e36-e41. PubMed: https://pubmed.ncbi.nlm.nih.gov/23656547/
  42. Berman J, Sudbery PE. Candida Albicans: a molecular revolution built on lessons from budding yeast. Nat Rev Genet. 2002; 3: 918-30. PubMed: https://pubmed.ncbi.nlm.nih.gov/12459722/
  43. O'Grady JF, Reade PC. Candida albicans as a promoter of oral mucosal neoplasia. Carcinogenesis. 1992; 13: 783-786. PubMed: https://pubmed.ncbi.nlm.nih.gov/1586990/
  44. Lodi G, Tarozzi M, Sardella A, Demarosi F, Canegallo L, et al. Miconazole as adjuvant therapy for oral lichen planus: a double-blind randomized controlled trial. Br J Dermatol, 2007; 156: 1336-1341. PubMed: https://pubmed.ncbi.nlm.nih.gov/17535232/
  45. de Sousa LVNF, Santos VL, de Souza Monteiro A, Dias-Souza MV, Marques SG, et al. Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype. BMC Infect Dis. 2016; 16: 86. PubMed: https://pubmed.ncbi.nlm.nih.gov/26905729/
  46. Williams DW, Jordan RPC, Wei XQ, Alves CT, Wise MP, et al. Interactions of Candida albicans with host epithelial surfaces. J Oral Microbiol. 2013; 5. PubMed: https://pubmed.ncbi.nlm.nih.gov/24155995/
  47. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, et al. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 100: 164-178. PubMed: https://pubmed.ncbi.nlm.nih.gov/16037774/
  48. Liu J, Geng F, Sun H, Wang X, Zhang H, et al. Candida albicans induces TLR2/MyD88/NF-κB signaling and inflammation in oral lichen planus-derived keratinocytes. J infect Dev Cries. 2018; 12: 780-786. PubMed: https://pubmed.ncbi.nlm.nih.gov/31999637/
  49. Hebbar PB, Pai A, Sujatha D, Mycological and histological associations of Candida in oral mucosal lesions. J Oral Sci. 2013; 55: 157-160. PubMed: https://pubmed.ncbi.nlm.nih.gov/23748455/
  50. Werneck JT, de Oliveira Costa T, Stibich CA, Leite CA, Dias EP, et al. Oral lichen planus: study of 21 cases. Anais Brasileiros de Dermatologia. 2015; 90: 321-326. PubMed: https://pubmed.ncbi.nlm.nih.gov/26131860/
  51. Duffey DC, Eversole LR, Abemayor E. Oral lichen planus and its association with squamous cell carcinoma: an update on pathogenesis and treatment implications. Laryngoscope. 1996; 106: 357-362. PubMed: https://pubmed.ncbi.nlm.nih.gov/8614204/
  52. Oberti L, Alberta L, Massimo P, Francesco C, Dorina L. Clinical Management of Oral Lichen Planus: A Systematic Review. Mini Rev Med Chem. 2019; 19: 1049-1059. PubMed: https://pubmed.ncbi.nlm.nih.gov/30836913/
  53. Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, et al. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature. 1999; 397: 530-534. PubMed: https://pubmed.ncbi.nlm.nih.gov/10028970/
  54. Laeijendecker R, van Joost T, Kuizinga MC, Tank B, Neumann HAM. Premalignant nature of oral lichen planus. Acta Derm Venereol. 2005; 85: 516-520. PubMed: https://pubmed.ncbi.nlm.nih.gov/16396800/
  55. Gorsky M, Epstein JB. Oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 111: 461-464. PubMed: https://pubmed.ncbi.nlm.nih.gov/21330164/
  56. von Krogh G, Dahlman-Ghozlan K, Syrjänen S. Potential human papillomavirus reactivation following topical corticosteroid therapy of genital lichen sclerosus and erosive lichen planus. J Eur Acad Dermatol Venereol. 2002; 16: 130-133. PubMed: https://pubmed.ncbi.nlm.nih.gov/12046814/
  57. Gandolfo S, Richiardi L, Carrozzo M, Broccoletti R, Carbone M, et al. Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 2004; 40: 77-83. PubMed: https://pubmed.ncbi.nlm.nih.gov/14662419/
  58. Mignogna MD, Fedele S, Russo LL, Mignogna C, de Rosa G, et al. Field cancerization in oral lichen planus. Eur J Surg Oncol. 2007; 33: 383-389. PubMed: https://pubmed.ncbi.nlm.nih.gov/17084578/
  59. Otero-Rey EM, Suarez-Alen F, Peñamaria-Mallon M, Lopez-Lopez J, Blanco-Carrion A. Malignant transformation of oral lichen planus by a chronic inflammatory process. Use of topical corticosteroids to prevent this progression? Acta Odontol Scand. 2014; 72: 570-577. PubMed: https://pubmed.ncbi.nlm.nih.gov/24850508/
  60. Mattsson U, Magnusson B, Jontell M. Squamous cell carcinoma in a patient with oral lichen planus treated with topical application of tacrolimus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110: e19-25. PubMed: https://pubmed.ncbi.nlm.nih.gov/20610291/
  61. Becker JC, Houben R, Vetter CS, Bröcker EB. The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report. BMC Cancer. 2006; 6: 7. PubMed: https://pubmed.ncbi.nlm.nih.gov/16405733/
  62. Morita M, Asoda S, Tsunoda K, Soma T, Nakagawa T, et al. The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report. Odontology. 2017; 105: 262-266. PubMed: https://pubmed.ncbi.nlm.nih.gov/27368962/
  63. Rangel JB, Thuler LCS, Pinto J. Prevalence of hepatitis C virus infection and its impact on the prognosis of head and neck cancer patients. Oral Oncol. 2018; 87: 138-143. PubMed: https://pubmed.ncbi.nlm.nih.gov/30527229/
  64. Nagao Y, Sata M, Noguchi S, Seno'o T, Kinoshita M, et al. Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues. J Oral Pathol Med. 2000; 29: 259-266. PubMed: https://pubmed.ncbi.nlm.nih.gov/10890556/
  65. Su FH, Chang S, Chen P, Sung F, Huang S, et al. Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan. PLoS One. 2012; 7: e48109. PubMed: https://pubmed.ncbi.nlm.nih.gov/23133554/
  66. Fiorino S, Bacchi-Reggiani L, de Biase D, Fornelli A, Masetti M, et al. Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review. World J Gastroenterol. 2015; 21: 12896-12953. PubMed: https://pubmed.ncbi.nlm.nih.gov/26668515/
  67. Koike K. The oncogenic role of hepatitis C virus. Recent Results Cancer Res. 2014; 193: 97-111. PubMed: https://pubmed.ncbi.nlm.nih.gov/24008295/
  68. Sorensen HT, Friis S, Olsen JH, Thulstrup AM, Mellemkjaer L, et al. Risk of liver and other types of cancer in patients with cirrhosis: a nationwide cohort study in Denmark. Hepatology. 1998; 28: 921-925. PubMed: https://pubmed.ncbi.nlm.nih.gov/9755226/
  69. Nagao Y, Nishida N, Toyo-Oka L, Kawaguchi A, Amoroso A, et al. Genome-wide association study identifies risk variants for lichen planus in patients with hepatitis C virus infection. Clin Gastroenterol Hepatol. 2017; 15: 937-944. PubMed: https://pubmed.ncbi.nlm.nih.gov/28065765/
  70. Lodi G, Pellicano R, Carrozzo M. Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Oral Dis. 2010; 16: 601-612. PubMed: https://pubmed.ncbi.nlm.nih.gov/20412447/
  71. Carbone M, Arduino PG, Carrozzo M, Gandolfo S, Argiolas MR, et al. Course of oral lichen planus: a retrospective study of 808 northern Italian patients. Oral Dis. 2009; 15: 235-243. PubMed: https://pubmed.ncbi.nlm.nih.gov/19222766/
  72. Baccaglini L, Thongprasom K, Carrozzo M, Bigby M. Urban legends series: lichen planus. Oral Dis. 2013; 19: 128-143. PubMed: https://pubmed.ncbi.nlm.nih.gov/22788669/
  73. Manomaivat T, Pongsiriwet S, Kuansuwan C, Thosaporn W, Tachasuttirut K, et al. Association between hepatitis C infections in Thai patients with oral lichen planus: A case-control study. J Investig Clin Dent. 2018; 9: e12316. PubMed: https://pubmed.ncbi.nlm.nih.gov/29345111/

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