Abstract

Literature Review

The protective potential of Carbonic Anhydrase VI (CA VI) against tooth decay in children: A systematic review of the literature

Daniele de Cassia Rodrigues Picco*, Lenita Marangoni Lopes, Carolina Steiner-Oliveira and Marinês Nobre dos Santos

Published: 02 August, 2022 | Volume 6 - Issue 1 | Pages: 021-027

Carbonic anhydrase VI (CA VI) catalyzes the reversible hydration of carbon dioxide in saliva with possible pH regulation, taste perception, and tooth formation effects. 
Objective: The aim of this work was to undertake a systematic review regarding the relationship between the expression/activity of CA VI in saliva and in dental biofilm and caries experience. 
Study design: Five databases were searched until February 2020. The composition was based on the PRISMA statement and on the PICOS model. First author, year, subject characteristics, analysis performed, outcome, measures & variables were extracted. The used terms were “carbonic anhydrase VI”, “saliva”, “dental biofilm” and “dental caries”.
Results: Five studies in the English language were selected for this systematic review and the main discussed topics were the expression/activity of CA VI in saliva and/or in the dental biofilm of children, and its relationship with dental caries. 
Conclusion: Salivary carbonic anhydrase plays an important role in the caries dynamics process since there is an association between the expression/activity of CA VI in saliva and the experience of caries. Thus, this protein can predict the risk of dental caries in young patients.

Read Full Article HTML DOI: 10.29328/journal.jcad.1001028 Cite this Article Read Full Article PDF

Keywords:

Carbonic anhydrases; Saliva; Dental plaque; “Children” and “Dental caries

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