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Articles by China Medical University

Intravascular leiomyoma misdiagnosed as deep vein thrombosis: A case report

Published on: 30th June, 2021

OCLC Number/Unique Identifier: 9272372470

Background: Leiomyoma itself is not a rare disease, but it is rarely found intravascularly. Case presentation: A 54-year old female sought medical help after noticing her leg being swelling. A diagnosis of deep vein thrombosis (DVT) was made and antithrombotic treatment was given after her initial imaging exam. Several days later, a contrast CT and sequential pathology revealed the real diagnosis was intravascular leiomyoma. The patient was discharged after a successful surgery. Conclusion: Intravascular leiomyoma should not be confused with DVT.
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Stability of facial soft tissue contour and bone wall at single maxillary tooth gap in early implant placement with contour augmentation: A case report

Published on: 23rd December, 2020

OCLC Number/Unique Identifier: 8872696999

Stability of esthetic implant buccal soft and hard tissue contour using freeze-dried bone allograft in early implant placement with contour augmentation.
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Blockage of asymmetric arginine dimethylation of NF-κB and specific knockdown of PRMT4 suppressed lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells

Published on: 17th November, 2021

Prolonged inflammation reactions lead to chronic diseases. Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) has been implicated in inflammatory disorders. Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to their substrates in cellular methylation reactions. PRMTs are emerging as targets for drug discovery because PRMTs are implicated in normal physiology and human diseases. Adenosine dialdehyde (AdOx), a broad-spectrum methyltransferase inhibitor, inhibited lipopolysaccharide and interferon-γ (LPS/IFNγ)-stimulated NO production and iNOS mRNA and protein expression in MES-13 cells. AdOx blocked nuclear factor- κB (NF-κB) nuclear translocation but showed no effect on signal transducer and activator of transcription-1α (STAT-1α) signaling pathway in MES-13 cells. Asymmetrical dimethylation of NF-κB identified by immunoprecipation with ASYM24 antibody was blocked by AMI-1, a specific arginine methyltransferase inhibitor. Moreover, AMI-1 and specific knockdown of protein arginine methyltransferase 4 (PRMT4) with small interfering RNA (siRNA) showed an inhibitory effect on LPS/IFN-γ-stimulated NO and iNOS protein expression in MES-13 cells. Our data suggest asymmetric arginine dimethylation of NF-κB may be implicated in inflammatory disorders though controlling the synthesis of NO, a key mediator in immune activation. The exploration of specific PRMTs, such as PRMT4, involved in iNOS-derived NO synthesis might provide therapeutic applications in treatment of chronic inflammatory diseases.
Cite this ArticleCrossMarkPublonsHarvard Library HOLLISGrowKudosResearchGateBase SearchOAI PMHAcademic MicrosoftScilitSemantic ScholarUniversite de ParisUW LibrariesSJSU King LibrarySJSU King LibraryNUS LibraryMcGillDET KGL BIBLiOTEKJCU DiscoveryUniversidad De LimaWorldCatVU on WorldCat